Polymeric N-Acetyl-D-Glucosamine (Chitin) Induces Prostaglandin E2 in Dogs

Saburo MINAMI; Yoshiharu OKAMOTO; Akira MATSUHASHI; Hitoshi SASHIWA; Hiroyuki SAIMOTO; Yoshihiro SHIGEMASA; Takahiko TANIGAWA; Takao SUZUKI; Shin-ichiro TANIOKA; Yoshinori TANAKA

doi:10.1292/jvms.57.377

Polymeric N-Acetyl-D-Glucosamine (Chitin) Induces Prostaglandin E₂ in Dogs

Saburo MINAMI, Yoshiharu OKAMOTO, Akira MATSUHASHI, Hitoshi SASHIWA, Hiroyuki SAIMOTO, Yoshihiro SHIGEMASA, Takahiko TANIGAWA, Takao SUZUKI, Shin-ichiro TANIOKA, Yoshinori TANAKA

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Keywords: canine, chitin, prostaglandin E₂

JOURNAL FREE ACCESS

1995 Volume 57 Issue 2 Pages 377-378

DOI https://doi.org/10.1292/jvms.57.377

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Abstract

The level of prostaglandin E₂ (PGE₂) in the exudate induced by subcutaneous implantation of a complex formed from non-woven fabric of polyester (NWF) and polymeric N-acety1-D-glucosamine (chitin) (chitin/NWF) or by implantation of NWF in dogs was measured by radioimmunoassay. The amount of PGE₂ in the exudate induced by chitin/NWF was about five times as high as that in the exudate induced by NWF (p<0.05), while the level of PGE₂ in the exudate was similar to that ip serum.

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