Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Effect of Extracellular Matrix on Two Cell Lines Established from Mongolian Gerbil's (Meriones unguiculatus) Malignant Melanoma
Osamu HASHIMOTOKenji OGAWAMasamichi KUROHMARUYoshihiro HAYASHI
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1995 Volume 57 Issue 4 Pages 635-640

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Abstract

We investigated the effect of extracellular matrix (ECM) on the adhesion, morphology and proliferation of two Mongolian gerbil's melanoma cell lines (MGM-S, MGM-A) which differed in malignancy. Fibronectin matrix was detected on the cell surface of MGM-S by immunofluorescence techniques. MGM-A cells, showing a multipolar shape, were widely spread over the dishes coated with fibronectin, laminin or type IV collagen. The adhesion rate of MGM-A cells to ECM components was higher compared to that in controls. Attachment to laminin was conspicuously promoted. The effect of laminin on MGM-A cell growth was also the highest among the substrates examined. On the other hand, these ECM components did not affect MGM-S cells. These results suggest that laminin and fibronectin may participate in the malignancy of MGM cell lines.

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© The Japanese Society of Veterinary Science
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