Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Antagonistic Effects of Atipamezole on Medetomidine-Induced Sedation in Horses
Kazuto YAMASHITAKasumi YONEZAWAYasuharu IZUMISAWATadao KOTANI
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1996 Volume 58 Issue 10 Pages 1049-1052

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Abstract

The antagonistic effects of atipamezole (20, 40, 60, 80, and 100μg/kg IV) on medetomidine (10 μg/kg IV)-induced sedation were evaluated in horses. Although 20 and 40μg/kg of atipamezole were not sufficient to reverse the sedation, 60μg/kg did effectively reverse the sedation. Atipamezole at 80μg/kg was more potent, and significantly shortened the duration of sedation without any apparent side effects, but a higher dose of 100μg/kg was not more effective than 80μg/kg. The possible use of atipamezole as a reversal agent may enhance the value and availability of medetomidine as a chemical restraint agent in horses.

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