ゲルトネル腸炎菌感染マウスに関する病理組織学的研究
第1編脾及びリンパ節の組織像について
1962 年 12 巻 5 号 p. 324-333
詳細
1962 年 12 巻 5 号 p. 324-333
In this paper, the histopathological study of the spleen and the lymph nodes of mice having infected with virulent or attenuated S. enteritidis, was reported as a part of fundamental study of experimental salmonellosis.
The group of mice infected with 10-7 mg or 10-2 mg microorganismus of virulent strain, almost died within 6 days in cause of septicaemia. On the contrary, the group with 10-5 mg of attenuated strain were no death entirely, and that obtained high igrade immunity 3 weeks after infection.
Pathohistologically, the spleen and the lymph nodes of mice with virulent strain showed a few tubercule, multiple necrosis in the reticular tissue, and many bacterial colonies in the blood vessel and necrotic tissues. On the other hand, mice with attenuated strain exhibited formation of multipel tubercules, reticuloendotheliosis and no bacterial colony, in the spleen and the lymph nodes, and that proliferatiion of myeloid cells sround the trabeculae of the spleen, multiplication of plasma cell with many Rassel, s bodies and reticular stimulating cells (Lennert) on the lymphatic medullary cord, were characterized by this group.
It is considered that those several pathohistological finding were related to reaction of mechanism immunized with living bacteria, as well as tubercule.
