胃癌組織の核酸代謝に関する研究

主としてDNA代謝について

抄録

The RNA content, the DNA content, the ratio RNA/DNA and the incorporation of thymidine-C¹⁴ into the DNA were biochemically studied on the gastric cancer tissue and the gastric ulcer tissue.
1. As to RNA content there was no significant difference between the gastric cancer tissue and their control tissue or the gastric ulcer tissue. DNA content incresed in the gastric cancer tissue. Emphasis should be laid on the fact that the incorporation of thymidine-C¹⁴ into DNA in the gastric cancr tissue increased and on the contrary, in the gastric ulcer tissue decreased.
2. Administration of Mitomycin C by intra-arterial infusion to gastric cancer caused a slight decrease in the incorporation of thymidine-C¹⁴ into DNA.
The data suggest that the anticancer agent (Mitomycin C) produces inhibiting effect on the DNA metabolism in gastric cancer tissue.