抄録
Electron microscopic changes in the chief cell of the canine gastric gland after cinchophen administion were investigated, as compared with those after insulin administration.
The chief cells in the normal dog in response to cinchophen decreased in secretory granules, showing a picture of increasing excretion on the luminal surface.The Golgi cisternae were enlarged, indicating a marked production of secretory granules, and rough-surfaced endoplasmic reticula showed parallel disposition in contrast with distorted irregular arrangement seen after insulin administration.
In stalk-sectioned dogs, cinchophen in contrast with insulin failed to accelerate the secretion of the gastric chief cells : There were many secretory granules, their excretion was hardly discernible in the lumen of the cells, and the Golgi cisternae were scarcely enlarged, indicating very poor production of secretory granles, and rough-surfaced endoplasmic reticula were arranged in parallal and dispersed disposition.
In vagotomized dogs, secretory granules were found numerously after cinchophcn administraion, and their excretion was demonstrated to a considerable degree, whereas it was scarce after insulin administration. Enlargement of the Golgi cisternae and production of secretory granules were not remarkable, and rough-surfaced endoplasmic reticula showed a parallel disposition.
It is considered from these findings that cinchophen accelerates the secretion of the gastric chief cells, and that the acceleration is inhibited strongly by pituitary stalk section and also to a lesser degree by vagotomy.
