ラツト横隔膜法に於ける糖基礎攝取能とInsulin効果との相関性について

抄録

1. Linear regression was observed within a definite range between glucose basal uptake and insulin effect investigated by the rat diaphragm method.
2. By changing glucose and insulin concentration in the incubation medium, alteration in various factors related with this regression line was sought. It was found that the regression line turned with one end fixed at the constant MBUcal value - the theoretical maximum basal uptake shown by hemidiaphragm - when glucose concentration was varied, and at the point of the constant MIEcal value - the theoretical maximum insulin effect shown by hemidiaphragm - when insulin concentration was varied.
3. An attempt was made to take, as the metameter for insulin determination, the absolute value of the regression coefficient of the relation between the basal uptake and the insulin effect. As the results, the following values were obtained concerning a regression line expressing relation between the logarithm of insulin concentration and absolute value of the regression coefficient : s=0.212, b=+1.345, λ= 0.158.
4. Change in glucose uptake, produced by change in the composition of diet, occurred along the regression line between the basal uptake and the insulin effect. Fluctuations in the measured values due to errors in prepearing the diaphragm sample and in determining glucose level was irrelevant of the regression line.
5. A few points were discussed concerning the action mechanism and biological evidence of various factors affecting correlation between the basal uptake and insulin effect.