1994 年 25 巻 4 号 p. 579-583
The usefulness of neoadjuvant chemotherapy of antitumor agent HCFU was evaluated in ten patients with colonic cancer using, as indices, TSIR and effects on tissues. There were significant differences in TSIR between parts of oral or anal to the incision and normal mucous membrane. As for effects on tissues, specimens from five patients were found in grade 0 and those from other five in grade IIA. The TSIR of patients whose tissues showed negative effects was 37.0±6.68 %, while the TSIR of patients with positive effects was 58.3±24.35 % which was significantly higher than the former. The mean dose of the antitumor agent administered to patients with negative effects was 5.7±0.36g, while that to patients with positive effects was 11.0±4.74g which was significantly larger than the former. Although there were no correlations between TSIR and tissue effects, it was considered that the antitumor agent could be expected to be clinically effective in patients whose TSIR were higher than 50 %, as the TSIR of patients with positive tissue effects were 58.3%. However, details must be studied on problems such as conditions in analyses, correlations between TSIR and tissue effects, evaluation of tissue effects, and correlations between preoperative antitumor treatments and postoperative outcomes. Furthermore, accumulation of cases with clinically effective TSIR and long-term follow up of patients are needed.
