キャピラリーGC/MSにおける大試料量注入

その1: GC/MSインターフェイスとしてのジェットセパレータの検討

抄録

Large sample volume injection method, 10 to 100 μl, into a capillary column using a packed column injector has many advantages over such ordinary injection methods as split and splitless injections. In order to apply this injection system to a magnetic sector-type mass spectrometer, a jet separator with a solvent cut shutter slit between a jet nozzle and an ion source is selected as a GC/MS interface. As a result, the detection limit was remarkably improved over 10 times in both TIC and SIM detection modes. For example, the detection limits for the methyl stearate by injecting 50 μl of the sample were 50 ppb and 10 ppt in TIC and SIM modes, respectively. The problems to be improved are also discussed.