Online ISSN : 1884-6440
Print ISSN : 0385-1036
ISSN-L : 0385-1036
久保井 亮一 馬越 大島内 寿徳
ジャーナル オープンアクセス

2007 年 32 巻 1 号 p. 32-39


The diseases caused by the membrane disorder or damages are categorized as the Membrane-related diseases. Alzheimer’s disease (AD), which is one of the membrane-related diseases, has been considered to be accompanied by the oxidative damage of the neuronal cell membrane. Amyloid β-peptide (Aβ), which is a pathological key peptide of AD, interacts with biomembrane and this interaction has been recently paid attention from the viewpoints of not only conformational abnormality but also the influence to biomembrane. And therefore, the modeling of biomembrane using liposome has been desired to develop the liposome-based sensor system. In this article, we surveyed the sensor system using liposome. Firstly, the immobilization techniques for preparation of the immobilized-liposome sensor are surveyed. Secondary, some kinds of sensor have been introduced: (i) (metal affinity) immobilized-liposome chromatography, (ii) immobilized-liposome quartz crystal microbalance method, (iii) immobilized-liposome sensor (Amperometric method), (iv) membrane chip system. These techniques have been developed in a framework of “Membrane Stress Biotechnology”. The above methodologies could provide us the quantitative properties of stress responsive function of both the protein and the membrane.

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