2021 Volume 64 Pages 62-68
It has been known that “loss of hair follicle stem cells due to aging” is one of the factor of thinning hair. In recent years, it became clear that the reduction of a special type collagen (type 17 collagen: COL17) present in the vicinity of hair follicle stem cells was largely involved in the mechanism. However, because it is difficult to directly ingest COL17 by applying hair restorer or taking supplement, it is necessary to promote the production of COL17 in hair follicle stem cells and nearby cell groups. The problems are permeability and delivery of components into cells.
We have developed poly-lactide-co-glycolide acid nanoparticles (PLGA NP) as a DDS carrier and reported that skin permeability and sustainability of the effect and intracellular of ingredient encapsulated could be enhanced.
In this paper, we report the effectiveness of chlorogenic acid encapsulated PLGA nanoparticles that have effects of promoting the production of COL17 and the activation of hair follicle stem cells.
