Erect of Ochratozin A on Protein Synthesis and Immanoresponse

Abstract

The mycotoxin ochratoxin A (OTA) has antibiotic properties. By analysing these pro-perties, a competitive inhibition of phenylalanyl-tRNA synthetase (PheRS) was found. This type of enzyme was inhibited in the same manner in higher cells too. Increased concen-trations of phenylalanine, therefore, in vivo prevented several effects of OTA in animal systems. The reason of an inducible resistance to OTA of B. subtilis was found to be due to increased of PheRS. A ochratoxin A resistant constitutive mutant had an altered PheRS. Ochratoxin A and 4R-OH-ochratoxin A acted as immunosuppressors, whereas ochratoxin a did not.