抄録
A 39-year-old woman had noticed several red bean-sized erythemas on both legs since 1966, and these erythemas had been gradually spread over the trunk in three years. She appeared in our clinic at first on December, 1969. At her first visit she had had generalized exfoliative dermatitis with severe itching, and hyperkeratotic palms and soles. In addition the skin of trunk, neck and extremities had revealed many solid papules and several nodules. The hairs of scalp, axillae and pubis were so sparse. In clinical examinations, they showed no abnormal findings except for leucocytosis (15,500/mm3) and atypical mononuclear cells (8%) which had PAS positive and diastase non-resistant granules in a wreath like arrangement at peripheral cytoplasm. Histologic specimen of the skin nodule showed parakeratosis, acanthosis, elongation of rete ridges, microabscesses in the upper epidermis and mononuclear cell infiltration in the dermis with a few eosinophiles and lymphocytes. Numerous mitotic figures of infiltrated cells were also found. The inguinal lymphnode showed the same cell infiltration as the skin nodule. She had been treated with injection of methotrexate and corticosteroids in mouth. She died of cachexia and autopsy revealed swelling of generalized lymphnodes, liver and spleen (mononuclear cell infiltration). No paticular finding in the bone marrow. The characteristics of Sézary’s cell and the relationship between Sézary’s syndrome and mycosis fungoides were discussed.
