Malignant Schwannoma of the Sciatic Nerve Originating in a Spinal Plexiform Neurofibroma Associated With Neurofibromatosis Type 1 —Case Report—

Cahide TOPSAKAL; Ismail AKDEMIR; Murat TIFTIKCI; Ibrahim OZERCAN; Yunus AYDIN

doi:10.2176/nmc.41.551

Case Reports

Malignant Schwannoma of the Sciatic Nerve Originating in a Spinal Plexiform Neurofibroma Associated With Neurofibromatosis Type 1

—Case Report—

Cahide TOPSAKAL, Ismail AKDEMIR, Murat TIFTIKCI, Ibrahim OZERCAN, Yunus AYDIN

著者情報

キーワード: neurilemmoma, neurofibroma, malignant peripheral nerve sheath tumor, malignant schwannoma, von Recklinghausen's disease

ジャーナルオープンアクセス

2001 年 41 巻 11 号 p. 551-555

DOI https://doi.org/10.2176/nmc.41.551

詳細

抄録

A 26-year-old man with neurofibromatosis type 1 (NF1) presented with a giant malignant schwannoma of the sciatic nerve. The differential diagnosis of malignant peripheral nerve sheath tumor (MPNST) was based on clinical, radiological, and histological evidence. The tumor apparently originated in a spinal plexiform neurofibroma. The lesion was resected totally without neural damage to the sciatic nerve. However, the tumor recurred within 2 months. The patient died of unknown factors probably associated with the spinal involvement. MPNST associated with NF1 has a poor prognosis due to recurrence or metastasis despite complete macroscopic removal.

責任著者(Corresponding author)

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