Discrepancy Between [18F]fluorodeoxyglucose and 11C-methionine Positron Emission Tomography Findings in Sturge-Weber Syndrome —Case Report—

Tsutomu ICHINOSE; Naohiro TSUYUGUCHI; Michiharu MORINO; Ichiro SUNADA; Kenji OHATA; Toshihiro TAKAMI; Yoshihiro SHIMONISHI; Joji KAWABE; Susumu SHIOMI; Mitsuhiro HARA

doi:10.2176/nmc.43.461

Case Reports

Discrepancy Between [¹⁸F]fluorodeoxyglucose and ¹¹C-methionine Positron Emission Tomography Findings in Sturge-Weber Syndrome

—Case Report—

Tsutomu ICHINOSE, Naohiro TSUYUGUCHI, Michiharu MORINO, Ichiro SUNADA, Kenji OHATA, Toshihiro TAKAMI, Yoshihiro SHIMONISHI, Joji KAWABE, Susumu SHIOMI, Mitsuhiro HARA

著者情報

キーワード: positron emission tomography, methionine, [¹⁸F]fluorodeoxyglucose, single photon emission computed tomography, Sturge-Weber syndrome

ジャーナルオープンアクセス

2003 年 43 巻 9 号 p. 461-464

DOI https://doi.org/10.2176/nmc.43.461

詳細

抄録

Cerebral blood flow and metabolism were evaluated in an adult with symptomatic intractable epilepsy and Sturge-Weber syndrome (SWS) manifesting as angiomas in the left cerebral hemisphere. ^99mTc-ethylcysteinate dimer single photon emission computed tomography detected reduced blood flow in the entire left cerebral hemisphere, and [¹⁸F]fluorodeoxyglucose positron emission tomography (PET) showed decreased glucose metabolism in the left cerebral hemisphere. These findings indicated hypofunction of the left cerebral hemisphere, which caused the right hemiparesis. ¹¹C-methionine (¹¹C-Met) PET revealed high ¹¹C-Met accumulation in the angiomas in the left cerebral hemisphere. Immunostaining for glial fibrillary acidic protein showed positive reaction in the lesions. Gliosis is a likely mechanism for the ¹¹C-Met accumulation, which is possibly associated with progressive calcification in the angiomas and retarded growth of patients with SWS occurring over many years.

責任著者(Corresponding author)

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