Resection of Gliomas Using Positron Emission Tomography/Computed Tomography Neuronavigation

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Two patients presented with provisional diagnoses of glioma. Computed tomography (CT) and magnetic resonance imaging failed to show the boundaries of the tumor clearly. Positron emission tomography (PET)/CT with [¹⁸F]fluorodeoxyglucose and ¹¹C-methionine clearly showed the location, extent, and heterogeneity of the tumors. The tumors were resected under PET/CT neuronavigation guidance. Histological examination of the specimens showed that PET/CT neuronavigation provided reliable distinction between normal brain and glioma, and that the uptake of PET tracers can indicate the degree of proliferation.