抄録
Immunological responses of C57BL/6 mice against syngeneic methylcholanthrene-induced glioma (203-glioma) were investigated by the methods of microcytotoxicity assay and adoptive transfer test. Following results were obtained. Spleen and lymph node cells from glioma-bearing mice were cytotoxic for glioma cells. Cytotoxic activity was specific to glioma cells and was almost completely eliminated by treatment with anti-Thy-1, 2 serum and complement. When 106 viable 203-glioma cells were inoculated subcutaneously, T cell-mediated cytotoxicity of spleen cells appeared significantly on day 5, and the peak of cytotoxic activity were observed on day 14 (68.9 ?? 73.8% cytolysis). Following this initial increase of cytotoxicity, it decreased gradually while the volume of the tumor increased rapidly. These studies indicate that glioma-bearing hosts possess T lymphocytes that can be cytotoxic for glioma and can suppress tumor growth.
