抄録
This is a case of primary glioblastoma multiforme in the cerebellum of a 33-year-old female with four months' clinical history. One month prior to admission, she had a sudden onset of severe vertigo, diplopia and headache, and then became unconscious. When admitted to the hospital on December 24, 1974, she was somnolent, and showed respiratory distress, stiff neck, bilateral papilledema, upward gaze palsy, bilateral abducens palsy, tetraparesis, and cerebeller signs such as ataxia and hypotonus of all limbs. Angiography and conray ventriculography disclosed a mass in the cerebellum. Posterior fossa exploration uncovered the mass in the inferior vermis. Partial removal of the tumor was performed. While irradiated by Linac in doses of 2, 600 rads, when she became dyspneic. The patient's condition deteriorated rapidly and she died two months after the operation.
Autopsy revealed that the tumor was situated in the inferior vermis and had infiltrated the bilateral cerebeller hemispheres. Meningeal dissemination in the basal cistern and in the spinal subarachnoidal space, and ventricular seeding were observed. Subcapsular tumor metastases to the liver were also recognized, probably via blood stream. Histological diagnosis of the cerebeller tumor was typical glioblastoma multiforme.
Approximately 44 cases of cerebellar glioblastoma, including our case, have been reported in assorted literature. Clinical features and pathological characteristics are critically reviewed.
