抄録
Fluosol-DA, 20% is a newly developed synthetic perfluorochemical emulsion experimentally known to be biologically inert, non-toxic and to have a high oxygen carrying capacity. On this basis, the effect of its administration was evaluated in cases of cerebral ischemia.
A total of 51 administrations was performed in 24 patients suffering from symptomatic cerebral vasospasm due to ruptured aneurysms. Their neurological conditions were evaluated before and after intravenous infusion at a dose of 10 ml/kg in 60 minutes. Regional cerebral blood flow and power spectrum displayed EEG were recorded in 2 and 6 patients, respectively. Fifteen cases (62%) out of twenty four (28/51 times of administration) showed improvement of disturbed consciousness and/or motor weakness which continued for about 24 hours after the administration. The solution was not effective in 9 cases (38%). No aggravation was observed. Cases with anterior communicating artery aneurysms had a better improvement ratio (10/11 cases, 18/24 times) than those with aneurysms located in other regions (5/13 cases, 10/27 times). The solution more effectively improved motor weakness (14/27 times) than disturbed consciousness (18/49 times). Mild consciousness disturbance was found to improve better (16/39 times) than severe disturbance. Marked increase of regional cerebral blood flow (Case 7) or the appearance of α wave on EEG (Case 24) were observed in accordance with the improvement of the conditions.
From these clinical data, Fluosol-DA, 20% is considered to be an effective treatment for the improvement of cerebral ischemia due to vasospasm.
