抄録
Systematic anterior pituitary function tests were performed in 23 patients with cerebral infarction in the region of the middle cerebral artery, and the results were assessed for correlation with various clinical factors.
By radio-immunoassay, growth hormone and cortisol during the insulin tolerance test (regular insulin, 0.15-0.20 U/kg), luteinizing hormone and follicle stimulating hormone under luteinizing hormone-releasing hormone (100μg), thyroid stimulating hormone and prolactin under thyroidreleasing hormone (500μg) were determined. The impaired rate was calculated in each patient as the percentage of the number of impaired anterior pituitary hormones in the number of effectively examined anterior pituitary hormones. The data were statistically assessed by variance analysis for sex, age, consciousness level, disease stage at the test time, type of computed tomography scan, and complications versus the impaired rate. The results were as follows: 1) Growth hormone, thyroid stimulating hormone, cortisol, luteinizing hormone, prolactin, and follicle stimulating hormone secretions were impaired in 65%, 52%, 26%, 17%, 17%, and 9% of the cases, respectively. 2) The case incidence of impaired anterior pituitary hormonal secretion was 83%, but its intensity was mild in most of the patients. 3) The impaired rate was significantly high in patients with consciousness disturbance and complications such as cerebral edema. 4) The impaired rate tended to be high in patients in the early stages of the disease.
