Hypotensive Effect of Anthocyanin-rich Extract from Purple-fleshed Sweet Potato Cultivar “Ayamurasaki” in Spontaneously Hypertensive Rats

Abstract

We prepared anthocyanin-rich extract from purple-fleshed sweet potato (Ipomoea batatas (L.) Lam.) cultivar “Ayamurasaki” (PSP-ANT) and examined hypotensive effect of PSP-ANT in spontaneously hypertensive rats (SHR). After a single ingestion (400 mg/kg p.o.) of PSP-ANT, a significant decrease of systolic blood pressure (p<0.05) was observed at 2 hours postadministration and the decrease was prolonged until 8 hours postadministration in SHR. The antihypertensive effect was also observed in a long-term ingestion (0.1 and 0.2% diet for 8 weeks) of PSP-ANT in SHR. After stopping the feed of PSP-ANT, the systolic blood pressure was almost the same as that of SHR fed control diet.