An Angiotensin I-converting Enzyme (ACE)-inhibitory Peptide Derived from Chicken Collagen Hydrolysate Lowers Blood Pressure in Spontaneously Hypertensive Rats

Abstract

We studied the antihypertensive effect of an octapeptide (Gly-Ala-Hyp-Gly-Leu-Hyp-Gly-Pro), which is derived from chicken collagen hydrolysates and has strong angiotensin I-converting enzyme (ACE)-inhibitory activity, on spontaneously hypertensive rats (SHRs). 6h after a single oral administration of the octapeptide (4.5mg/kg SHR body weight), the systolic blood pressure was significantly reduced. The octapeptide was not digested by digestive enzymes from the epithelia of the porcine small intestines in vitro. These results suggest that this ACE-inhibitory peptide is absorbed by SHRs in the peptide form and that it lowers blood pressure.