Salmon Muscle Extract Containing Anserine as a Suppressor of Fatigue in Humans

Abstract

Migratory fish and birds have muscles rich in anserine to maintain posture and instantaneous power. The anti-fatigue activity of anserine was first determined by a forced-swimming test on mice. Here, we conducted exercise tolerance testing on physically normal men to evaluate the anti-fatigue effect of salmon muscle extract containing anserine (SEAns) in a clinical test. SEAns inhibited creatine phosphokinase activity, suppressed elevation of the cortisol level in blood, and improved exercise endurance. From these results, we conclude that SEAns reduces physical fatigue and mental stress.