Effect of Dietary Chinese Yam (D. opposita Thunb.) and Leaf Juice (Aojiru) on Aberrant Crypt Foci Formation in 1, 2-Dimethylhydrazine-treated Mice

Abstract

The dietary effects of Chinese yam, nagaimo (Dioscorea opposita Thunb.), on 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) formation in the large intestine of mice were investigated and compared with those of other potato species. Potato consumption was found to significantly suppress ACF formation in the large intestines of all mice treated with DMH. Suppression of ACF formation was most remarkable in the nagaimo group. Moreover, the commercial product (aojiru) containing nagaimo powder also suppressed ACF formation.