Effects of a Single Ingestion of Green Coffee Bean Chlorogenic Acids on Facial Skin Properties—A Randomized, Placebo-Controlled, Crossover Study—

Abstract

Coffee bean chlorogenic acids, the major components of coffee polyphenols, have various physiological effects in humans such as anti-obesity, anti-hypertension and skin hydration when continuously ingested. Recently, it was reported that a single ingestion of coffee bean chlorogenic acids (CGAs) extracted from green coffee beans improved skin blood flow (SkBF) recovery after cold stress. On the other hand, it was observed that increases in skin hydration and transepidermal water loss (TEWL) were accompanied by a transient increase of SkBF. Thus, a single ingestion of CGAs is also expected to increase skin hydration. In this study, we investigated the effects of a single ingestion of CGAs on facial skin properties. A randomized, placebo-controlled, crossover intervention study was conducted in healthy adult women. Skin hydration, TEWL and SkBF were measured on the cheeks of subjects before and at 60 and 120 min after the ingestion of 270 mg CGAs or a placebo with a 1-week washout period. Twenty subjects were enrolled and all completed the study. Significant increases of skin hydration, TEWL and SkBF were observed in the CGAs group at 60 and 120 min compared with the placebo group. These findings suggest that a single ingestion of CGAs transiently increases skin hydration, TEWL and SkBF.