1998 Volume 45 Issue 11 Pages 671-675
Izumi-shrimp (Plesionika izumiae Omori, 1971) is one of the unused resources, which are caught at southern coast of Tokushima Prefecture. In order to develop its utilization, possible physiological function was investigated using stroke-prone spontaneously hypertensive rats (SHRSP). The hot water extract of izumi-shrimp and the digested residual protein by Protease S (hydrolysate) showed an angiotensin 1-converting enzyme (ACE) inhibitory activity in vitro. A single oral administration of the hydrolysate with a molecular weight of less than 5000 significantly decreased blood pressure of 8 and 12 weeks old SHRSP, which was continued for 1hr after the treatment. Both the hot water extract and the hydrolysate significantly inhibited age-associated spontaneous increase of blood pressure in SHRSP and also tended to retard the incidence of stroke. These results suggested that the presence of ACE inhibitory substances in the hot water extract or the hydrolysate of izumi-shrimp contribute for developing a new foodstuff with anti-hypertensive activity.
