Abstract
We examined the effects of hot-water extracted polysaccharides from either Agaricus blazei or Tricholma giganteum on antitumor activity and NO production. No obvious effects on survival rate and antitumor activity were observed in Tricholma giganteum-administrated male C57 BL/6 mice implanted B16-melanoma cell. Moreover, pulmonary metastasis was observed in a Tricholma giganteum-treated tumor-bearing mice. NO productions from normal mouse peritoneal macrophage were examined. Although polysaccharides from Tricholma giganteum and Agaricus blazei were significantly increased NO production in a dose-dependent manner, those of Tricholma giganteum was lower effect than those of Agaricus blazei. These results suggest that the polysaccharides from Tricholma giganteum have very little or negligible immunological function compared with those from Agaricus blazei.
