抄録
Highly blood-compatible titania and carbonate-hydroxyapatite for blood purification therapy were prepared and adsorption of some pathogenic substances was studied. Titania was prepared by hydrolyzing tetraethylorthotitanate and calcination. Bilirubin (causing hyperbilirubinemia) and albumin were adsorbed on the titania powder. Either entrapping bilirubin in the pores or electrostatic interaction between bilirubin and the titania surface was effective for the adsorption of bilirubin. Carbonate-containing apatites were synthesized in CO2-containing N2 atmosphere by a wet chemical method using calcium nitrate and diammonium hydrogenphosphate, and by subsequent calcination. Infrared (IR) spectroscopic analysis indicated that the carbonate ions substituted both PO43- and OH- sites. The apatites were contacted with a solution containing both bovine serum albumin (BSA) and b2-microglobulin (b2-MG) that causes amiloydosis. Better selectivity for b2-MG adsorption was empirically correlated to the carbonate ions incorporated in the hydroxyapatite lattice.
