メンブレンクロマトグラフィーMustang^®による分離精製技術

抄録

Mustang^® is composed of microporous modified hydrophilic polyethersulfone (PES) membranes, having uniform coating with quaternary amine (Q) group and sulfonic acid (S) group. Mustang^® membrane chromatography shows high binding capacity even under the high flow rate, by its larger pore size, and convective surface structure. Therefore, Mustang^® purification technology has merit as a simple, speedy, and scalable one, especially for removing of harmful factors and impurities in bioprocess purification, and also the purification of macromolecules like DNA, virus, plasmid, and proteins etc. Here it is introduced the examples of the viral/DNA removal, and adenovirus vector purification using Mustang^® membrane chromatography. Safety and quality assurance can be added into manufacturing process of biological drugs by applying and strengthen this separation and purification technology.