A 32-year-old female with epigastric pain visited our clinic. Esophagogastroduodenoscopy revealed multiple antral erosions and notch-like depressions in the second portion of the duodenum that were typical of Crohn's disease. Colonoscopy revealed no lesions in the small intestine, colon, and anus. Sulpiride was prescribed and her symptom resolved, indicating functional dyspepsia. We diagnosed Crohn's disease localized only in the upper gastrointestinal tract. No granuloma was detected on biopsy examination. We prescribed an elemental diet, mesalazine, and milled mesalazine. Esophagogastroduodenoscopy and colonoscopy were performed annually for six years. The erosions and depressions did not change, and no new lesions appeared in other parts of the gastrointestinal tract. There has been no domestic report of long-term, quiescent Crohn's disease. Although this case does not fulfill the diagnostic criteria, we report this rare case of Crohn's disease.
