シンポジウムI 消耗性凝固障害
a. Consumption coagulopathyにおける血栓形成のTriggerについて
1972 年 13 巻 2 号 p. 151-156
詳細
1972 年 13 巻 2 号 p. 151-156
Investigations were conducted on th changes of contact factor activity
(1) by the administration of tissue thromboplastin, bacterial endotoxin, saturated or unsaturated fatty acids intravenously to rabbits, (2) by the administration of either animal fat or vegitable fat to normal fasting people in the early morning. Furthermore, in vitro, the differences of the activation of the contact factor by the different fatty acids were examined.
The results were:
(1) Following the infusion of either tissue thromboplastin or bacterial endotoxin to rabbits, the activated form of contact factor increased in pararell with the shortening of silicone PTT.
(2) Following the infusion of long-chain fatty acid to rabbits, only saturated fatty acid initiated contact factor activation.
(3) Following the administration of animal fat to normal person, long-chain fatty acid was increased and he contact factor was activated.
(4) In the in vitro experiment, the long-chain fatty acid produced a remerkable activation of the contact factor.
Conclusion:
It was concluded that tissue thromboplastin, bacterial endotoxin and the long-chain saturated fatty acid act as the triggers in the initial stage of intravascular coagulation syndrome by activating contact factor.
