抄録
A 7-year-old boy who was diagnosed as having acute lymphocytic leukemia in December 1974, had been treated with combined chemotherapy and cranial irradiation.
After the sixth relapse, he became resistant to combined chemotherapy.
He received drip infusion of bone marrow cells (5.7×108/kg) from the elder brother with identical HLA A, B and D antigens. Conditioning regimen consisted of cyclophosphamide and total body irradiation. During transplantation he was nursed in reverse isolation room. For prevention of graft-versus-host reaction (GVHR), he was given methorexate 15mg/M2 on the day of trasplantation followed by 10mg/M2 on 3, 5, 10th day and on weekly basis thereafter.
Nadir of white blood cell count (200/mm3) was six days after transplantation. He had been maintained neutrophil count above 500/mm3 after the 19th day. Disappearance of blast cells in bone marrow was in the 5th week. After then he never received blood component transfusions. Grade II GVHR was noticed around the third week and subsided around the twelveth week.
He developed the third generalized Herpes zoster infection in the twelveth week and sebsequently expired with heart failure due to lung edema sixteen weeks after transplantation.
Necropsy revealed bone marrow remained free of disease although leukemic infiltration with tumor formation in the lungs, liver, kidneys, pancreas and testicles.
