抄録
Sera from patients with various diseases and healthy controls were tested for antibodies to adult T-cell leukemia (ATL)-associated antigens (ATLA). In T-cell maligancy, 25 of 27 cases of ATL, 4 of 7 cases of mycosis fungoides, 1 of 2 cases of Sézary syndrome, 4 of 11 cases of T-lymphoma and 1 of 1 case of T-CLL were anti-ATLA positive with titers of 1:10 to 1:1, 280. Of these 35 anti-ATLA positive cases, 2 had received blood transfusion, while there was no history of blood transfusion in 23 and no information of blood transfusion in 10. On the other hand, in non-T-cell malignancy, 9 of 130 cases of hematologic malignancy, 1 of 28 cases of hematologic non-malignancy, 6 of 50 cases of non-hematologic diseases and 4 of 454 healthy controls were anti-ATLA positive with titers of 1:10 to 1:1, 280. Of these 20 anti-ATLA positive cases, 15 had been given blood transfusion, massive in most of them, and the other 5 had no history of blood transfusion. One of AML patients seroconverted from anti-ATLA negative to positive after 2 months while receiving massive blood transfusion. Therefore, anti-ATLA positivity in persons other than patients with T-cell malignancy is likely to be transfusion-related seroconversion.
