抄録
A fourty-one year old male from Oita Pref. was critically ill with fever, generalized ery thematous rash, lymphadenopathy, and hepatosplenomegaly on admission when ninetysix per cent of peripheral WBC (18×104/mm3) was found to be E+ RFC, with convoluted nuclei and pleomorphic morphology of these abnormal lymphocytes. These lymphocytes were positive to surface immunoglobulin test. ATLA antibody was positive. The diagnosis was made readily as ATL. Skin biopsy to the erythematous rash showed infiltrations of the leukemic cells in the dermis, also in the epidermis with scattered Pautriér's microabscesses. Right inguinal lymphnode biopsy was diagnosed of diffuse, pleomorphic cell type lymphoma. An electron microscopic study of ATL cells from this patient revealed peculiar features, such a sannulate lamellae, membranous aggregates and intranuclear inclusion bodies. Such Structures, which have not yet been reported in ATL cells, seem to be related to an accelerated rate of metabolic activities of leukemic T-cells undergoing abrupt cell proliferation.
