抄録
From 1972 to 1982, 13 children with non-Hodgkin's lymphoma (NHL) were treated. Only one out of five patients who were treated before 1976 was survived 69+months. Intensive chemotherapy “Regimen 1” with high-dose methotrexate (50-150mg/kg, 6 hours intravenous infusion) followed by citrovorum factor rescue (H-D-MTX) was initiated on seven cases scince 1976. Complete remission was obtained in four cases (57%) with “Regimen 1”. All of these four cases were in long-term remission ranging from 22+ to 46+ months with cyclic maintenance therapy consisting of vincristine, prednisolone, adriamycin, 6-MP, and H-D-MTX. One of three patients treated by modified LSA2L2 protocol because of resistant to H-D-MTX was survived 23+months with no evidence of disease.
The peak serum concentration of MTX was linearly increased to 10-4∼10-3 M with dosage of 50-300mg/kg. The CSF MTX concentration was also dose dependent increment and achieved 10-6M level with dosage over than 100mg/kg.
The clinical toxicities of H-D-MTX were limted in nausea and vomiting. No life-threating toxicity was observed.
