抄録
A 62-year-old female with lymphoma type adult T cell leukemia (ATL) was treated by high dose chemoradiotherapy and autologous bone marrow transplantation.
67Ga scan and CT scan disclosed only left cervical lymphadenopathy. Abnormal cells and HTLV proviral DNA were demonstrated in lymph node cells, but not in peripheral blood lymphocytes or bone marrow cells.
By local irradiation and combination chemotherapy, left cervical lymph node disappeared. Prior to transplantation, she was given large dose cyclophosphamide and 10 Gy total body irradiation. On March 7, 1984, cryopreserved autologus bone marrow cells were thawed and infused into the patient.
Five weeks after transplantation, granulocytes and platelets were restored. In the next week, however, ATL cells appeared in the peripheral blood, and the patient died of hypercalcemia and acute renal failure.
Autologous bone marrow transplantation may be one approach for the treatment of lymphoma type ATL.
