抄録
Candidiasis of the liver developed during the initial remission induction treatment in two patients with acute promyelocytic leukemia. Both patients experienced abdominal pain, high fever and hepatomegaly, and the second patient developed strikingly elevated serum alkaline phosphatase (ALP). Ultrasonography demonstrated intrahepatic lesions of increased echogenecity and CT scan revealed low-density areas without contrast enhancement. A quantitative measurement of anticandida antibody level confirmed that deep-seated candida infection had occured. The second patient underwent treatment with amphotericin B, 5-FC and minocycline without success. It is important to make prophylactic use of amphotericin B in patients with acute leukemia even during initial remission induction therapy.
