We reported two children with acute myelogenous leukemia with an 8/21 translocation.
The first case, a six-year-old girl, was hospitalized because of fever in November, 1984. Her hemoglobin was 11.0 g/dl, 19,500/mm3 with 10% leukemic blasts, and platelets 187,000/mm3. Her bone marrow was normocellular with 6.0% abnormal cells. She was diagnosed as M2 according to the FAB classification. Peripheral and bone marrow chromosomal analysis by G-banding revealed 46, X, X, +t (8; 21) (q22; q22). Interestingly, she is accompanied with bilateral nevus depigmentosus.
To our knowledge, the second case was the youngest patient reported in Japan with AML (M2) and t (8; 21). A two-year-old male infant was admitted to our hospital because of fever. He was diagnosed as AML (M2) and peripheral chromosomal analysis by G-banding revealed t (8; 21) associated with a missing Y chromosome. Despite DCMP therapy, he developed tumors of orbit and mastoid and died of subarachnoidal hemorrhage.
