剖検時B-リンパ腫が確認されたHTLV-I関連T-リンパ腫の1例

抄録

A 56 years old Japanese female born in Kumamoto prefecture was admitted to the Nagasaki Municipal Hospital in Febuary, 1983 because of cervical lymphadenopathy. She presented with systemic lymphadenopathy and multiple skin nodules. Lymph node biopsy revealed diffuse lymphoma, medium-sized cell type according to the LSG classification. The phenotype of neoplastic lymphocytes was S-Ig^-, E-R⁺, Leu-1⁺, Leu-2a^- and Leu-3a⁺. The HTLV-I proviral DNA was demonstrated by the Southern procedure. She was diagnosed to have HTLV-I-associated T-cell lymphoma, and was treated by the modified CHOP combination chemotherapy. The patient died of carinii pneumonitis in June, 1983.
The post-mortem examination revealed B-cell lymphoma (diffuse lymphoma, large cell type) by light and electron microscopy and immunoperoxidase staining. We discussed a relationship between HTLV-I and the malignancies other than adult T-cell leukemia.