抄録
Adhesion of colon cancer cells (colo 201) and neutrophils to endothelial cells which had been briefly treated with hypoxanthine/xanthine oxidase, hydrogen peroxide, or peroxynitrite was analyzed in the absence of de novo protein synthesis using actinomycin D or cycloheximide. Hypoxanthine/xanthine oxidase treatments accelerated the adhesion of both colo 201 cells and neutrophils to endothelial cells, and these effects were blocked by SOD/catalase or EDTA. These data provided preliminary evidence for the fact that hydroxyl radicals directly affect the cell surface of endothelial cells and accelerate cell adhesion.
