1987 年 24 巻 1 号 p. 31-35
Five healthy male subjects (19-22 years old) were immersed to the neck in ‘Kan-no-Jigoku’ spring water (13°C) for 15 min, twice a day, for consecutive 12 days. Venous blood samples for the measurements of glucose, free fatty acids (FFA) and insulin were drawn before and after the 1st, 7th, 13th, 19th and 23rd immersions. At the 1st immersion, no acute response in blood glucose to the cold-water stimulus was observed. However, blood glucose levels decreased at 15-60 min after each of the 7th to 23rd immersions. FFA levels showed an acute rise after every cold immersion, but the degree of the acute response in FFA gradually decreased during the course of the serial immersions. Basal insulin level tended to increase until the 7th day and to be maintained in a high level thereafter. These results suggest that either the mobilization of glucose and FFA decreased or the utilization of those substrates increased by the repeated cold-water immersions.