This paper have revealed the performance characteristic of the heat source system quantitatively by the simulation results under various operation conditions with wet-bulb temperature and cooling load ratio as parameters within the simplified heat source system. As a result, 'has become possible to show the effective range for the control of each accessory unit and relationship between wet-bulb temperature, load ratio of chiller and its range. Then the simple operation method of heat source system can be proposed and it is determined from wet-bulb temperature and cooling load. And, we installed the operation algorithm to a dynamic heat load simulation method for building and calculated the energy consumption of the heat source system which consists of multiple chillers. As a result, it is confirmed that the operation algorithm is extremely effective in energy conservation.