Retinal Ganglion Cell Density after Coenzyme Q10 Treatment in a Rat Model of Methanol Toxic Optic Neuropathy

抄録

Purpose: To compare the retinal ganglion cell (RGC) density in the control and coenzyme Q10-treated rat models of methanol toxic optic neuropathy (MTON).
Methods: This experimental animal study was conducted in 14 MTON model rats divided into two groups, the control group (I) and the coenzyme Q10 group (II). Both groups were exposed to N₂O:O₂ and orally administered methanol (3 g/kg body weight). After 4 h, the rats in the group II were orally administered coenzyme Q10. After 8 h, the eyes were enucleated and histopathological specimens were prepared. The specimens were imaged under a microscope at 200× magnification and the RGC densities were counted.
Results: The average RGC densities for the group I and group II were 36.57 (SD 5.84) and 57.67 (SD 7.63), respectively. A significant difference was identified between the two groups (p<0.001).
Conclusion: RGC density was higher in the MTON model rats that were treated with coenzyme Q10 compared to the control group.