クジラ鼻軟骨Proteinpolysaccharideからシアル酸含有ケラト硫酸類似ムコ多糖の分離

抄録

It was undertaken to clarify some properties of sialic acid-containing mucopolysaccharide (SP) occurring as a component of whale cartilage proteinpolysaccharide (PP). After enzymatic degradation of PP with hyaluronidase and Pronase, the products were chromatographed on Sephadex columns, and the behavior of SP on the columns was examined. Moreover, SP was fractionated into five fractions by Dowex 1-×2 chromatography, and these were analyzed for sialic acid, hexosamine, hexose, uronic acid, and sulfate. Consequently, it was clarified that SP was keratosulfate-like mucopolysaccharide containing a large amount of sialic acid as well as small amounts of galactosamine, mannose, and fucose.