大腸菌におけるトリメチルアミンN-オキサイド還元酵素の生成にたいする硝酸塩の阻害
1975 年 41 巻 9 号 p. 987-991
詳細
1975 年 41 巻 9 号 p. 987-991
The effects of nitrate on induced formation of trimethylamine N-oxide (TMO) reductase as well as on cell growth were examined in Escherichia coll. The addition of nitrate to a culture caused significant inhibition of the reductase formation in cells. Growth of cells was promoted by nitrate to the same extent as by TMO.
It was suggested that the combination of TMO as an inducer with cell enzyme induction systems obeys Michaelis-Menten kinetics. The inhibition of the enzyme formation by nitrate was proved to be non-competitive in nature. The inhibitor added to assay mixtures, however, did not affect at all the activity of the induced enzyme itself.
