海洋性Vibrioの生産する多糖体の抗腫瘍性及び免疫増強活性

抄録

Antitumor activity of the polysaccharide prepaation from marine Vibrio sp. and its effects on immune responses were studied by using mice.
Antitumor activities of the material were examined agained against P 388 leukemia and Sarcoma-180 solid tumor cells. The saccharide showed a weak antitumor activity against both tumors. In the test of lymphocyte responsiveness to phytohemagglutinin (PHA), the test sample reduced the immunological response to PHA. The cellular immune rsponses were measured by the delayed hypersensitivity reaction to sheep red blood cells using footpad assay. The preparation suppressed the production of antibody against sheep erythrocytes in mice at high doses. The appearance of antibody forming cells after the injection of sheep red blood cell antigen was studied by the plaque technique. The number of plaque forming cells without treatment of this material is about 1×10⁴ cells per spleen, which increased to about 5×10⁴ by treatment of this materia.