The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Regular Contributions
Rise in Plasma Oxidized Glutathione by Experimental Hypoglycemia
Zhong-Li Jiang, Tokutaro Sato
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キーワード: hypoglycemia, reduced glutathione (GSH), oxidized glutathione (GSSG)
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1999 年 187 巻 1 号 p. 59-64

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Changes in plasma glutathione were investigated under hypoglycemic status. Twelve rabbits were randomly divided into hypoglycemic group (n=6) and saline-injected control group (n=6). Hypoglycemia was induced by intravenous injection of insulin as 10 U/kg and recovered by intravenous glucose injection after 60 minutes. In the control group, saline was intravenously injected in stead of insulin. Plasma levels of oxidized glutathione (GSSG) rose significantly (p<0.01) and remarkably decrease in plasma GSH/GSSG ratio (p<0.05) accompanying increase in serum enzymes in the hypoglycemic group. These results suggest that hypoglycemia might cause change in plasma GSSG which is related to increase of serum enzymes by hypoglycemia.
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© 1999 Tohoku University Medical Press
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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