Abstract
Perfusions of 34 isolated canine kidneys were performed at 38°C using heparinized diluted homologous blood, and the effects of vasodilators on renal circulation and urinary output were studied. Renal pressure, renal blood flow, renal vascular resistance, urine volume, glomerular filtration rate by creatinine clearance method, and intrarenal distribution of blood flow by 131I-tagged serum albumin method were measured before and after the administration of drugs, and the following results were obtained. Papaverine and mannitol were effective in improving the circulation through the isolated kidney when proper doses were given. ATP showed biphasic effects depending on its concentration. Phenoxybenzamine isoproterenol and bradykinin showed no significant vasodilating effect on the isolated kidney perfusion.
