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Volume 101 (1970)
- Issue 4 Pages 299-
- Issue 3 Pages 205-
- Issue 2 Pages 103-
- Issue 1 Pages 1-
Volume 101, Issue 2
Displaying 1-9 of 9 articles from this issue
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SHOICHI YAMAGATA, HISAYUKI MASUDA, AKIRA ISHIMORI, SHUICHI INOUE, TAKE ...1970 Volume 101 Issue 2 Pages 103-117
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSUsing a new synthetic gastrin-like AOC-tetrapeptide (t-amyloxy•carbonyl•Try•Met•Asp •Phe•NH2), a multicenter pilot study was carried out to assess its clinical utility for the analysis of gastric conditions. Computer analysis revealed that 4μg of the drug per kg body weight yielded the maximal acid secretory response, which was characterized by an earlier appearance of a higher maximal response value than with betazole hydrochloride of 1mg per kg body weight. Maximal AOC-tetrapeptide test enabled discrimination between cases of endoscopically normal gastric mucosa and those of duodenal ulcer relatively well, but the differential diagnosis was unsatisfactory in cases of some endoscopically distinguishable conditions of the stomach such as normal stomach, atrophic gastritis, gastric ulcer and duodenal ulcer. It is particularly noteworthy that no side effect was observed during the entire experiment.View full abstractDownload PDF (717K) -
TOHRU TAKAHASHI1970 Volume 101 Issue 2 Pages 119-140
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe vascularization of the normal human liver as revealed by the graphical reconstruction of the vascular trees was characterized by regular inter. digitation of the portal and hepatic veins with uniform distance. The lobular pattern of the liver was found entirely to depend upon the particular orientation of the afferent and efferent vessels, and the concept of the hepatic lobule as a preformed structural unit could not be sustained.
A histometrical method was described to estimate the length L of the shortest routes through points randomly taken in an-organ. The distribution of L could be approximated by a normal distribution, so that a ratio Lmax/Lmin, the largest and smallest Ls at 3σ;-level respectively, indicated the inequality in the length of the capillary routes and consequently the irregularity of the vascular interdigitation of each organ. The ratio was smallest in the liver with a value of about 3 and largest in the renal cortex exceeding 50 among the examined organs.
In organs with small Lmax/Lmin, a non-regulatory and steady peripheral circulation was assumed, while alternate or regulatory flow, which developed from intermittent flow of the afferent vessels on account of their regulatory activity, was considered necessary to sustain the peripheral circulation of organs with large Lmax/Lmin.View full abstractDownload PDF (4194K) -
SHIGERU ONO, MASAO HATANO, KIJURO OBARA1970 Volume 101 Issue 2 Pages 141-145
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe effects of hypophysectomy and of growth hormone administration on in vitro incorporation of 14C-labeled leucine into protein of isolated rat cornea were studied. The most striking effects observed were: (1) diminution of leucine incorporation into whole cornea and of corneal protein fraction after hypophysectomy, and (2) the reduction of the leucine incorporation in cornea from hyphysectomized animals could be reversed by administration of growth hormone. These findings suggested that the hypophyseal function is one of the important factors in controlling the synthesis of protein in cornea.View full abstractDownload PDF (258K) -
RIKURO SASAKI, TOSHIAKI MORISHITA, SHOICHI YAMAGATA1970 Volume 101 Issue 2 Pages 147-152
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe total numbers of heart muscle cells and of interstitial cells were estimated in the Goldblatt rats by a histometrical method. The thickness of muscle fibers and the length of muscle cells were also estimated. The heart weight and heart muscle volume increased significantly in the hypertensive group. The total number of heart muscle cells was 30-54 millions in the hypertensive group, while it was 25-38 millions in the control group. The total number of interstitial cells was 88-102 millions in the hypertensive group and 72-87 millions in the control group. There was a significant increase of both cells in the hypertensive group. Both the total number of heart muscle cells and that of interstitial cells were proportional to the heart muscle volume. There were no significant differences in the thickness of muscle fibers and in the length of muscle cells between the two groups. It was concluded that the heart weight and heart muscle volume increased in the hypertensive group, and the increase in heart muscle volume was due to an increase in the cell number. Hyperplasia of the muscle cells rather than their hypertrophy was regarded as the major process underlying cardiac hypertrophy.View full abstractDownload PDF (352K) -
RIKURO SASAKI, TOSHIAKI MORISHITA, SHOICHI YAMAGATA1970 Volume 101 Issue 2 Pages 153-159
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSTotal DNA content of the whole heart muscle of the Goldblatt rats was chemically determined, and the DNA content per single nucleus of the heart muscle cell and of the interstitial cell was determined by the microspectrophotometric method, in order to substantiate the assumption of cell division of the heart muscle in experimental cardiac hypertrophy. Total DNA content of the whole heart muscle and the DNA content per 100mg of heart weight in the hypertensive group was significantly higher than those in the control group. The DNA content per nucleus of the muscle cell and of interstitial cell was found to be constant in both groups. It seems that the increase in DNA content indicates the increase in the number of heart muscle cells as well as of interstitial cells.View full abstractDownload PDF (414K) -
CHEN TIE HWANG, EIAKI TSUTSUMI, HIROSHI SUZUKI, KAZUHIKO TAKANO, NAOYA ...1970 Volume 101 Issue 2 Pages 161-173
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSPerfusions of 34 isolated canine kidneys were performed at 38°C using heparinized diluted homologous blood, and the effects of vasodilators on renal circulation and urinary output were studied. Renal pressure, renal blood flow, renal vascular resistance, urine volume, glomerular filtration rate by creatinine clearance method, and intrarenal distribution of blood flow by 131I-tagged serum albumin method were measured before and after the administration of drugs, and the following results were obtained. Papaverine and mannitol were effective in improving the circulation through the isolated kidney when proper doses were given. ATP showed biphasic effects depending on its concentration. Phenoxybenzamine isoproterenol and bradykinin showed no significant vasodilating effect on the isolated kidney perfusion.View full abstractDownload PDF (669K) -
KAZUHIKO TAKANO, EIAKI TSYTSUMI, HIROSHI SUZUKI, CHEN-TIH HWANG, MAKOT ...1970 Volume 101 Issue 2 Pages 175-181
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe effect of administration of a longterm perfused plasma on the peripheral circulation was studied by means of the equilibration curve of intravenously injected 51Cr-tagged red cells. The equilibration of 51Cr-tagged red cells was prolonged when a long-term perfused plasma was injected. LMD and ATP were effective in preventing the disturbance of circulation caused by denatured plasma; insulin and NEM were less effective; and cortisone showed a significantly favorable effect. Sequestration of blood in various organs could not be comfirmed in rabbits to which denatured plasma was injected.View full abstractDownload PDF (392K) -
SHIGEFUMI FUJIMURA, TASUKU NAKADA, MINORU KAWAKAMI, TADAYOSHI SUKENO, ...1970 Volume 101 Issue 2 Pages 183-198
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe histochemical examination by the fluorescent antibody method for demonstrating the localization of immunoglobulins (γM and γG) in lung allografts and other lymphoid tissues of the recipients was performed in canine lung allotransplantation. Histologic and immunohistologic observations of the transplanted lungs of the non-treated group seemed to be characterized by initial appearance of pyroninepositive cells and γM-containing cells around the small vessels and bronchioli. In the graft of the treated group, appearance of pyronine-positive cells and of γM positive cells was most dominant at the time of rejection. According to immunofluorescent stain, γM- and γG-positive cells were apparently observed in the lymphoid tissues of the recipient at the time of rejection. Accordingly. γM-containing cells seemed to play an important role in the rejection of the lung transplant.View full abstractDownload PDF (4888K) -
SHINJI TAKAHASHI, YOSHIAKI TANAKA1970 Volume 101 Issue 2 Pages 199-203
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn order to simplify the troublesome procedure of chromatoroentgenography described in the previous method (Tohoku J. Exp. Med., 1969, 98, 213), the medical X-ray color film was produced for trial and used. The film was coated with emulsion containing magenta coupler on the front side, and cyan and yellow couplers on the back side. The exposure dose for this X-ray antihalation color film was almost three times that for usual X-ray film. No remarkable difference was observed on the image quality between the usual roentgenogram and chromatoroentgenogram. The processing time was almost half or less than that for the ehromatoroentgenogram taken with usual X-ray film. When applied to human body, this method provides more information than the normal roentgenography does.View full abstractDownload PDF (1279K)
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