Clot Promoting Activity and Activities of Clotting Factors in Lyophilized Serum

Abstract

The clot promoting activity and activities of clotting factors in lyophilized serum were the same with those in fresh serum. The clot promoting activity of lyophilized serum to control plasma and PTC deficient plasma was stable at room temperature for eight months at least. For the purpose to measure the clot promoting activity in serum, an assay for “clot promoting serum factor (s), (CPSF)” was done. There was a linear relationship between the kaolin PTT of normal plasma mixed with serum and the log of serum concentration as measured 1/10 diluted serum containing 100% CPSF activity. Compared with fresh serum, lyophilized serum is much easier to use and to transport, with less danger of contamination and better toleration for a long storage for emergency use, and it is considered to be more beneficial in practical use for serum transfusion in hemostatic procedure.